Article

Repair of DNA double-strand breaks after low radiation doses in childhood cancer survivors and matched cancer-free individuals

2025-12-23

Abstract excerpt

DNA double-strand breaks (DSBs) which arise in G1- or G0-phase normal human cells are repaired by non-homologous end-joining (NHEJ), a pathway which is important for cell survival but can cause mutations at the break sites. DSB repair by NHEJ is very efficient at high damage levels of 1 or more DSBs per cell, much less efficient at lower damage levels and almost absent if only ∼0.05 DSBs per cell are induced. Repa...

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Literature Corpus work: 28265f22-c396-5ec1-958b-7b3591132521
DOI: 10.64898/2025.12.22.695953

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