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Article

Thiopurine Methyltransferase Genotype Predicts Therapy-Limiting Severe Toxicity from Azathioprine

1 Nov 1998

Abstract excerpt

BACKGROUND: Substantial hematologic toxicity limits the use of azathioprine. OBJECTIVE: To evaluate 1) polymorphic inactivation of azathioprine by thiopurine methyltransferase and 2) clinical toxicity. DESIGN: Prospective cohort study. SETTING: Two rheumatology units. PATIENTS: 67 patients for whom azathioprine was prescribed as second-line therapy for rheumatic disease. MEASUREMENTS: Polymerase chain...

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Identifiers

PMID: 9841604
DOI: 10.7326/0003-4819-129-9-199811010-00007

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Thiopurine Methyltransferase Genotype Predicts Therapy-Limiting Severe Toxicity from AzathioprinePMID 9841604Read ↗

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Utility of thiopurine methyltransferase genotyping and phenotyping, and measurement of azathioprine metabolites in the management of patients with autoimmune hepatitis.Semantic proximity Read ↗

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Thiopurine S-Methyltransferase Polymorphisms Predict Hepatotoxicity in Azathioprine-Treated Patients with Autoimmune DiseasesSemantic proximity Read ↗

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