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Article

Detection of MDR1 single nucleotide polymorphisms C3435T and G2677T using real-time polymerase chain reaction: MDR1 single nucleotide polymorphism genotyping assay.

AAPS pharmSci - 1 Jan 2002

Song Pengfei, Li Shen, Meibohm Bernd, Gaber A Osama, Honaker Marsha R, Kotb Malak, Yates Charles R

Abstract excerpt

The objective of this study was to develop a real-time polymerase chain reaction (PCR) method to detect MDR1 (human multidrug resistance gene) single nucleotide polymorphisms (SNPs) C3435T and G2677T. C3435T and G2677T are linked to MDR1*2, which is associated with enhanced efflux activity in vitro. Using the Smart Cycler, an allele-specific real-time PCR-based genotyping method was developed to detect C3435T and...

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PMID: 12646001
DOI: 10.1208/ps040429
PMCID: PMC2751318

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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