Article
Increased expression and no mutation of the Flap endonuclease (FEN1) gene in human lung cancer.
Oncogene - 16 Oct 2003
Sato Mitsuo, Girard Luc, Sekine Ikuo, Sunaga Noriaki, Ramirez Ruben D, Kamibayashi Craig, Minna John D
Abstract excerpt
The underlying molecular mechanisms leading to microsatellite alteration and mutations in human lung cancer remain unknown. Since Flap endonuclease1 (Fen1), which functions in the base excision repair system, has been shown to be involved in tumor progression of mouse models with microsatellite instability in a haplo-insufficient manner, we performed expression and mutation analyses for FEN1 in human lung cancer...
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