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Article

Intracellular long-chain acyl CoAs activate TRPV1 channels.

PloS one - 1 Jan 2014

Yu Yi, Carter Chris R J, Youssef Nermeen, Dyck Jason R B, Light Peter E

Abstract excerpt

TRPV1 channels are an important class of membrane proteins that play an integral role in the regulation of intracellular cations such as calcium in many different tissue types. The anionic phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) is a known positive modulator of TRPV1 channels and the negatively charged phosphate groups interact with several basic amino acid residues in the proximal C-terminal...

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Identifiers

PMID: 24798548
DOI: 10.1371/journal.pone.0096597
PMCID: PMC4010479

Genes

TRPV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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