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Article

Lack of evidence for association of high altitude pulmonary edema and polymorphisms of the NO pathway.

High altitude medicine & biology - 1 Jan 2003

Weiss Johanna, Haefeli Walter Emil, Gasse Christiane, Hoffmann Michael Marcus, Weyman Jörn, Gibbs Simon, Mansmann Ulrich, Bärtsch Peter

Abstract excerpt

One essential factor in the development of high altitude pulmonary edema (HAPE) is elevated pulmonary artery pressure, possibly due to a lack of nitric oxide (NO) in pulmonary vessels. NOS3 gene polymorphisms (G894T, T-786C, and CA-repeats > or =38) might be linked to decreased NO synthesis and increased susceptibility to HAPE, while the C242T polymorphism of the CYBA gene [encoding for the NAD(P)H oxidase...

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Source

Identifiers

PMID: 14561241
DOI: 10.1089/152702903769192313

Genes

NOS3
CYBA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Lack of evidence for association of high altitude pulmonary edema and polymorphisms of the NO pathway.PMID 14561241Read ↗

Polymorphisms of angiotensin converting enzyme and nitric oxide synthase 3 genes as risk factors of high-altitude pulmonary edema: a case-control study and meta-analysis.Semantic proximity Read ↗

Heterozygotes of NOS3 polymorphisms contribute to reduced nitrogen oxides in high-altitude pulmonary edema.Semantic proximity Read ↗

Association of endothelial nitric oxide synthase (eNOS) G894T polymorphism with high altitude pulmonary edema susceptibility: a meta-analysis.Semantic proximity Read ↗

Gene polymorphisms and high-altitude pulmonary edema susceptibility: a 2011 update.Semantic proximity Read ↗

Positive association of the endothelial nitric oxide synthase gene polymorphisms with high-altitude pulmonary edema.Semantic proximity Read ↗

Genetic differences and aberrant methylation in the apelin system predict the risk of high-altitude pulmonary edema.Semantic proximity Read ↗

Genotype at the missense G894T polymorphism (Glu298Asp) in the NOS3 gene is associated with susceptibility to acute mountain sickness.Semantic proximity Read ↗

Endothelial nitric oxide synthase polymorphisms do not influence pulmonary artery systolic pressure at altitude.Semantic proximity Read ↗

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Genetic adaptation to extreme hypoxia: study of high-altitude pulmonary edema in a three-generation Han Chinese family.Semantic proximity Read ↗

Rare mitochondrial DNA polymorphisms are associated with high altitude pulmonary edema (HAPE) susceptibility in Han Chinese.Semantic proximity Read ↗

Simultaneous selection of the wild-type genotypes of the G894T and 4B/ 4A polymorphisms of NOS3 associate with high-altitude adaptation.Semantic proximity Read ↗

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