Article
Positive association of the endothelial nitric oxide synthase gene polymorphisms with high-altitude pulmonary edema.
Circulation - 13 Aug 2002
Droma Yunden, Hanaoka Masayuki, Ota Masao, Katsuyama Yoshihiko, Koizumi Tomonobu, Fujimoto Keisaku, Kobayashi Toshio, Kubo Keishi
Abstract excerpt
BACKGROUND: A defect of nitric oxide (NO) synthesis in the lung of high-altitude pulmonary edema (HAPE) has been suggested to contribute to its exaggerated pulmonary hypertension. Several polymorphisms have been identified in the gene encoding endothelial nitric oxide synthase (eNOS), which is a key enzyme responsible for NO synthesis, some of which were reported to be associated with vascular disorders. METHODS...
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