Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic differences and aberrant methylation in the apelin system predict the risk of high-altitude pulmonary edema.

Proceedings of the National Academy of Sciences of the United States of America - 12 May 2015

Mishra Aastha, Kohli Samantha, Dua Sanchi, Thinlas Tashi, Mohammad Ghulam, Pasha M A Qadar

Abstract excerpt

Hypoxia-inducible factor stimulates the expression of apelin, a potent vasodilator, in response to reduced blood arterial oxygen saturation. However, aberrations in the apelin system impair pulmonary vascular function, potentially resulting in the development of high-altitude (HA)-related disorders. This study aimed to elucidate the genetic and epigenetic regulation of apelin, apelin receptor (APLNR), and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5' Untranslated Regions
Share to Altitude

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CpG Islands

Share to Intercellular Signaling Peptides and Proteins

Share to Nitric Oxide Synthase Type III

Share to Nitrites

Share to Oxygen

Share to Receptors, G-Protein-Coupled

Source

Open in PubMed Open full text

Identifiers

PMID: 25918383
DOI: 10.1073/pnas.1422759112
PMCID: PMC4434746

Genes

NOS3
APLNR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic differences and aberrant methylation in the apelin system predict the risk of high-altitude pulmonary edema.PMID 25918383Read ↗

Susceptibility to high-altitude pulmonary edema is associated with circulating miRNA levels under hypobaric hypoxia conditionsSemantic proximity Read ↗

Gene polymorphisms and high-altitude pulmonary edema susceptibility: a 2011 update.Semantic proximity Read ↗

Correlation between single nucleotide polymorphisms in hypoxia-related genes and susceptibility to acute high-altitude pulmonary edema.Semantic proximity Read ↗

DNA methylation in adaptation to high-altitude environments and pathogenesis of related diseasesSemantic proximity Read ↗

Genetic Associations with the Susceptibility to High-Altitude Pulmonary Edema in the Japanese Population.Semantic proximity Read ↗

Polymorphisms of angiotensin converting enzyme and nitric oxide synthase 3 genes as risk factors of high-altitude pulmonary edema: a case-control study and meta-analysis.Semantic proximity Read ↗

Long Non-coding RNA LINC-PINT and LINC00599 Polymorphisms are Associated With High-altitude Pulmonary Edema in Chinese.Semantic proximity Read ↗

High-altitude pulmonary edema is aggravated by risk loci and associated transcription factors in HIF-prolyl hydroxylases.Semantic proximity Read ↗

Whole transcriptome landscape in HAPE under the stress of environment at high altitudes: new insights into the mechanisms of hypobaric hypoxia toleranceSemantic proximity Read ↗

Genetic adaptation of the hypoxia-inducible factor pathway to oxygen pressure among eurasian human populations.Semantic proximity Read ↗

<i>EGLN1</i> variants influence expression and <i>S</i>a<scp>O</scp>2 levels to associate with high-altitude pulmonary oedema and adaptationSemantic proximity Read ↗

DNA Methylation Changes and Phenotypic Adaptations Induced Repeated Extreme Altitude Exposure at 8848 Meters.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.