Article
High epithelial and stromal genetic instability of chromosome 17 in ulcerative colitis-associated carcinogenesis.
Cancer research - 1 Oct 2003
Matsumoto Naoko, Yoshida Tsutomu, Okayasu Isao
Abstract excerpt
To define the relative frequencies of genetic instability in stromal and epithelial compartments during ulcerative colitis (UC)-associated tumorigenesis, samples from laser-captured microdissection were assessed for microsatellite instability and loss of heterozygosity in regenerative tissue, dysplasia, and carcinomas in long-standing UC cases. Five National Cancer Institute-recommended standard markers and four...
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