Article
The Rare-Variant Generalized Disequilibrium Test for Association Analysis of Nuclear and Extended Pedigrees with Application to Alzheimer Disease WGS Data.
American journal of human genetics - 2 Feb 2017
He Zongxiao, Zhang Di, Renton Alan E, Li Biao, Zhao Linhai, Wang Gao T, Goate Alison M, Mayeux Richard, Leal Suzanne M
Abstract excerpt
Whole-genome and exome sequence data can be cost-effectively generated for the detection of rare-variant (RV) associations in families. Causal variants that aggregate in families usually have larger effect sizes than those found in sporadic cases, so family-based designs can be a more powerful approach than population-based designs. Moreover, some family-based designs are robust to confounding due to population...
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