Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Specific inhibition of human immunodeficiency virus type 1 replication by antisense oligonucleotides: an in vitro model for treatment.

Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 1992

Lisziewicz J, Sun D, Klotman M, Agrawal S, Zamecnik P, Gallo R

Abstract excerpt

We have developed a culture system, simulating in vivo conditions of human immunodeficiency virus type 1 (HIV-1) infection, to evaluate the long-term efficacy of antisense oligonucleotide treatment. Five oligonucleotide phosphorothioates (28-mers), complementary to different regions of HIV-1 RNA, blocked replication of the virus in a sequence-specific manner at 1 microM concentration. Variations in antiviral...

Topics

Base Sequence
Cell Survival
Cells, Cultured
HIV-1
Humans
In Vitro Techniques
Molecular Sequence Data
Mutation
Oligonucleotides, Antisense
Time Factors
Virus Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 1454800
DOI: 10.1073/pnas.89.23.11209
PMCID: PMC50519

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1454800-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Specific inhibition of human immunodeficiency virus type 1 replication by antisense oligonucleotides: an in vitro model for treatment.PMID 1454800Read ↗

Antisense-mediated inhibition of human immunodeficiency virus (HIV) replication by use of an HIV type 1-based vector results in severely attenuated mutants incapable of developing resistance.Semantic proximity Read ↗

Antisense Oligonucleotide-Based Therapy of Viral InfectionsSemantic proximity Read ↗

Oligonucleotide antiviral therapeutics: Antisense and RNA interference for highly pathogenic RNA virusesSemantic proximity Read ↗

Human immunodeficiency virus type 1 escape from RNA interference.Semantic proximity Read ↗

Inhibition of HIV-1 replication in cultured cells with antisense oligonucleotides encapsulated in immunoliposomes.Semantic proximity Read ↗

Human immunodeficiency virus type 1 escapes from RNA interference-mediated inhibition.Semantic proximity Read ↗

Human immunodeficiency virus type 1 escape is restricted when conserved genome sequences are targeted by RNA interference.Semantic proximity Read ↗

Potent and Specific Inhibition of HIV Envelope-Mediated Cell Fusion and Virus Binding by G Quartet-Forming Oligonucleotide (ISIS 5320)Semantic proximity Read ↗

5-Azacytidine Can Induce Lethal Mutagenesis in Human Immunodeficiency Virus Type 1Semantic proximity Read ↗

Silencing Antibiotic Resistance with Antisense OligonucleotidesSemantic proximity Read ↗

Investigation of the Activity of LNA-Modified Phosphorothioate Oligonucleotides Against HIV-1Semantic proximity Read ↗

Modified comb-shaped antisense oligonucleotides may secure us against many important viral diseases including AIDSSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.