Article
Two distinct size classes of immature and mature subviral particles from tick-borne encephalitis virus.
Journal of virology - 1 Nov 2003
Allison Steven L, Tao Yizhi J, O'Riordain Gabriel, Mandl Christian W, Harrison Stephen C, Heinz Franz X
Abstract excerpt
Flaviviruses assemble in the endoplasmic reticulum by a mechanism that appears to be driven by lateral interactions between heterodimers of the envelope glycoproteins E and prM. Immature intracellular virus particles are then transported through the secretory pathway and converted to their mature form by cleavage of the prM protein by the cellular protease furin. Earlier studies showed that when the prM and E...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
