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Article

Cleavage of protein prM is necessary for infection of BHK-21 cells by tick-borne encephalitis virus.

The Journal of general virology - 1 Jan 2003

Elshuber Sigrid, Allison Steven L, Heinz Franz X, Mandl Christian W

Abstract excerpt

Flavivirus particles are synthesized in an immature form containing heterodimers of the proteins prM and E. Shortly before release from the cell, prM is cleaved by the host protease furin to yield mature virions. In this study, the furin-mediated cleavage of the tick-borne encephalitis (TBE) virus protein prM was prevented by specific mutagenesis of the cleavage site. This resulted in the production of immature...

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Identifiers

PMID: 12533715
DOI: 10.1099/vir.0.18723-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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