Article
Intracellular Assembly and Secretion of Recombinant Subviral Particles from Tick-Borne Encephalitis Virus
12 Mar 2003
Abstract excerpt
It is believed that flavivirus assembly occurs by intracellular budding of the nucleocapsid into the lumen of the endoplasmic reticulum (ER). Recombinant expression of tick-borne encephalitis (TBE) virus envelope proteins prM and E in mammalian cells leads to their incorporation into enveloped recombinant subviral particles (RSPs), which have been used as a model system for studying assembly and entry processes...
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