Article
Bayesian haplotype inference for multiple linked single-nucleotide polymorphisms.
American journal of human genetics - 1 Jan 2002
Niu Tianhua, Qin Zhaohui S, Xu Xiping, Liu Jun S
Abstract excerpt
Haplotypes have gained increasing attention in the mapping of complex-disease genes, because of the abundance of single-nucleotide polymorphisms (SNPs) and the limited power of conventional single-locus analyses. It has been shown that haplotype-inference methods such as Clark's algorithm, the expectation-maximization algorithm, and a coalescence-based iterative-sampling algorithm are fairly effective and...
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