Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Idiotype vaccination of multiple myeloma patients using monocyte-derived dendritic cells.

Haematologica - 1 Oct 2003

Reichardt Volker L, Milazzo Caterina, Brugger Wolfram, Einsele Hermann, Kanz Lothar, Brossart Peter

Abstract excerpt

BACKGROUND AND OBJECTIVES: Dendritic cells (DC) pulsed with multiple myeloma (MM) patient-specific idiotype (Id) protein can induce MM-specific T-cell responses. DESIGN AND METHODS: We established serum-free culture conditions to generate monocyte-derived DC for clinical use to circumvent anti-xenogenic immune responses with repetitive vaccinations. In a clinical phase I trial twelve patients responsive to high...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adjuvants, Immunologic
Share to Cancer Vaccines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Culture Media, Serum-Free

Share to Granulocyte-Macrophage Colony-Stimulating Factor

Share to Immunoglobulin Idiotypes

Share to Multiple Myeloma

Share to T-Lymphocytes, Cytotoxic

Share to Vaccination

Source

Identifiers

PMID: 14555310

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Idiotype vaccination of multiple myeloma patients using monocyte-derived dendritic cells.PMID 14555310Read ↗

Long-term effects of idiotype vaccination on the specific T-cell response in peripheral blood and bone marrow of multiple myeloma patients.Semantic proximity Read ↗

Compromised functionality of monocyte-derived dendritic cells in multiple myeloma patients may limit their use in cancer immunotherapy.Semantic proximity Read ↗

Ex vivo induction of multiple myeloma-specific cytotoxic T lymphocytes.Semantic proximity Read ↗

Efficient presentation of tumor idiotype to autologous T cells by CD83(+) dendritic cells derived from highly purified circulating CD14(+) monocytes in multiple myeloma patients.Semantic proximity Read ↗

Dendritic cells purified from myeloma are primed with tumor-specific antigen (idiotype) and activate CD4+ T cells.Semantic proximity Read ↗

Impaired functionality and phenotypic profile of dendritic cells from patients with multiple myeloma.Semantic proximity Read ↗

Induction of multiple myeloma-specific cytotoxic T lymphocyte stimulation by dendritic cell pulsing with purified and optimized myeloma cell lysates.Semantic proximity Read ↗

Dendritic cells generated from the blood of patients with multiple myeloma are phenotypically and functionally identical to those similarly produced from healthy donors.Semantic proximity Read ↗

Idiotype vaccines for non-Hodgkin's lymphoma induce polyclonal immune responses that cover mutated tumor idiotypes: comparison of different vaccine formulations.Semantic proximity Read ↗

Generation of CMRF-44+ monocyte-derived dendritic cells: insights into phenotype and function.Semantic proximity Read ↗

CMRF44+ dendritic cells from peripheral blood stem cell harvests of patients with myeloma as potential cellular vectors for idiotype vaccination.Semantic proximity Read ↗

Dendritic cell-based vaccines in the setting of peripheral blood stem cell transplantation: CD34+ cell-depleted mobilized peripheral blood can serve as a source of potent dendritic cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.