Article
Dendritic cell-based vaccines in the setting of peripheral blood stem cell transplantation: CD34+ cell-depleted mobilized peripheral blood can serve as a source of potent dendritic cells.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 1998
Choi D, Perrin M, Hoffmann S, Chang A E, Ratanatharathorn V, Uberti J, McDonagh K T, Mulé J J
Abstract excerpt
We are investigating the use of tumor-pulsed dendritic cell (DC)-based vaccines in the treatment of patients with advanced cancer. In the current study, we evaluated the feasibility of obtaining both CD34+ hematopoietic stem/ progenitor cells (HSCs) and functional DCs from the same leukapheresis collection in adequate numbers for both peripheral blood stem cell transplantation (PBSCT) and immunization purposes,...
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