Article
The prognostic significance of p53 tumor suppressor gene alterations in ovarian carcinoma.
Cancer - 1 Nov 2000
Shahin M S, Hughes J H, Sood A K, Buller R E
Abstract excerpt
BACKGROUND: The prognostic significance and nature of p53 dysfunction in ovarian carcinoma is unclear. The relation between p53 overexpression, p53 mutations, and their effects on overall survival in primary ovarian carcinoma is explored. METHODS: Tumor specimens from 171 consecutive epithelial ovarian carcinomas were examined for overexpression of p53 protein with DO7 antibody. P53 mutations were determined by...
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