Article
P53 mutations in advanced cancers: clinical characteristics, outcomes, and correlation between progression-free survival and bevacizumab-containing therapy.
Oncotarget - 1 May 2013
Said Rabin, Hong David S, Warneke Carla L, Lee J Jack, Wheler Jennifer J, Janku Filip, Naing Aung, Falchook Gerald S, Fu Siqing, Piha-Paul Sarina, Tsimberidou Apostolia M, Kurzrock Razelle
Abstract excerpt
BACKGROUND: Mutations in the p53 gene are amongst the most frequent aberrations seen in human cancer. Our objective was to characterize the clinical characteristics associated with p53 mutation in patients with advanced cancer. METHODS: We retrospectively reviewed and analyzed the clinical features and response to standard systemic therapy of 145 patients with documented tumor p53 mutational status (mutant-type...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.