Article
Development of sporadic microsatellite instability in colorectal tumors involves hypermethylation at methylated-in-tumor loci in adenoma.
The American journal of pathology - 1 Nov 2010
de Maat Michiel F G, Narita Norihiko, Benard Anne, Yoshimura Tetsunori, Kuo Christine, Tollenaar Rob A E M, de Miranda Noel F C C, Turner Roderick R, van de Velde Cornelis J H, Morreau Hans, Hoon Dave S B
Abstract excerpt
Microsatellite instability (MSI) and genomic hypermethylation of methylated-in-tumor (MINT) loci are both strong prognostic indicators in a subgroup of patients with sporadic colorectal cancer (CRC). The present study was designed to determine whether the methylation of MINT loci during the progression of adenoma to CRC is related to MSI in CRC cases. Methylation index (MI) was measured by absolute quantitative...
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