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Article

AU-rich elements in the collagenase 3 mRNA mediate stabilization of the transcript by cortisol in osteoblasts.

The Journal of biological chemistry - 13 Feb 2004

Rydziel Sheila, Delany Anne M, Canalis Ernesto

Abstract excerpt

Collagenase 3 degrades collagen fibrils and is necessary for bone resorption. Cortisol increases collagenase 3 mRNA in osteoblasts by stabilizing collagenase 3 transcripts. To understand mechanisms involved, we used RNA electrophoretic mobility shift assay and RNA turnover studies. Cortisol increased the binding of Ob cell cytosolic extracts to AU-rich sequences in the collagenase 3 3'-untranslated region (UTR)....

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Identifiers

PMID: 14645243
DOI: 10.1074/jbc.M311984200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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