Mutations of a Drosophila NPC1 gene confer sterol and ecdysone metabolic defects.

doi:10.1534/genetics.105.046565

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Article

Mutations of a Drosophila NPC1 gene confer sterol and ecdysone metabolic defects.

Genetics - 1 Jan 2006

Fluegel Megan L, Parker Tracey J, Pallanck Leo J

Abstract excerpt

The molecular mechanisms by which dietary cholesterol is trafficked within cells are poorly understood. Previous work indicates that the NPC1 family of proteins plays an important role in this process, although the precise functions performed by this protein family remain elusive. We have taken a genetic approach to further explore the NPC1 family in the fruit fly Drosophila melanogaster. The Drosophila genome...

Topics

Animals
Animals, Genetically Modified
Cholesterol, Dietary
Drosophila Proteins
Drosophila melanogaster
Ecdysterone
Female
Gene Expression Regulation, Developmental
Genes, Lethal
Genes, Recessive
Larva

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Membrane Proteins

Mutation

Neurosecretory Systems

Niemann-Pick C1 Protein

Niemann-Pick Diseases

Sterols

Source

Open in PubMed Open full text

Identifiers

PMID: 16079224
DOI: 10.1534/genetics.105.046565
PMCID: PMC1456146

Genes

NPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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