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Article

Neuronal loss of Drosophila NPC1a causes cholesterol aggregation and age-progressive neurodegeneration.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 25 Jun 2008

Phillips Scott E, Woodruff E A, Liang Ping, Patten Meaghan, Broadie Kendal

Abstract excerpt

The mistrafficking and consequent cytoplasmic accumulation of cholesterol and sphingolipids is linked to multiple neurodegenerative diseases. One class of disease, the sphingolipid storage diseases, includes Niemann-Pick disease type C (NPC), caused predominantly (95%) by mutation of the NPC1 gene. A disease model has been established through mutation of Drosophila NPC1a (dnpc1a). Null mutants display early...

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Identifiers

PMID: 18579730
DOI: 10.1523/JNEUROSCI.5529-07.2008
PMCID: PMC3306184

Genes

NPC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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