Article
dOCRL maintains immune cell quiescence by regulating endosomal traffic.
PLoS genetics - 1 Oct 2017
Del Signore Steven J, Biber Sarah A, Lehmann Katherine S, Heimler Stephanie R, Rosenfeld Benjamin H, Eskin Tania L, Sweeney Sean T, Rodal Avital A
Abstract excerpt
Lowe Syndrome is a developmental disorder characterized by eye, kidney, and neurological pathologies, and is caused by mutations in the phosphatidylinositol-5-phosphatase OCRL. OCRL plays diverse roles in endocytic and endolysosomal trafficking, cytokinesis, and ciliogenesis, but it is unclear which of these cellular functions underlie specific patient symptoms. Here, we show that mutation of Drosophila OCRL...
Topics
- Animals
- Cytokinesis
- Drosophila
- Endosomes
- Hemocytes
- Humans
- Immunity, Innate
- Mutation
- Oculocerebrorenal Syndrome
- Phosphoric Monoester Hydrolases
- Protein Binding