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Article

Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor).

Oncogene - 9 Oct 2003

Tolg Cornelia, Poon Raymoond, Fodde Riccardo, Turley Eva Ann, Alman Benjamin Aaron

Abstract excerpt

Aggressive fibromatosis (desmoid tumor) is a locally invasive soft tissue neoplasm associated with mutations resulting in beta-catenin-mediated transcriptional activation. This tumor is composed of cells with histological and molecular characteristics common to proliferating mesenchymal cells of dermal wounds. Using immunohistochemistry and RT-PCR, we show that Rhamm, a protein with an important role in wound...

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Source

Identifiers

PMID: 14534534
DOI: 10.1038/sj.onc.1206811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor).PMID 14534534Read ↗

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Clinical Activity of the γ-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors (Aggressive Fibromatosis).Semantic proximity Read ↗

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Mesenchymal stromal cell mutations and wound healing contribute to the etiology of desmoid tumors.Semantic proximity Read ↗

Increased connexin-43 and gap junctional communication correlate with altered phenotypic characteristics of cells overexpressing the receptor for hyaluronic acid-mediated motility.Semantic proximity Read ↗

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