Article
Aggressive fibromatosis (desmoid tumor) is derived from mesenchymal progenitor cells.
Cancer research - 1 Oct 2010
Wu Colleen, Amini-Nik Saeid, Nik-Amini Saied, Nadesan Puviindran, Stanford William L, Alman Benjamin A
Abstract excerpt
The cellular origins from which most tumors arise are poorly defined, especially in mesenchymal neoplasms. Aggressive fibromatosis, also known as desmoid tumor, is a locally invasive soft tissue tumor that has mesenchymal characteristics. We found that aggressive fibromatosis tumors express genes and cell surface markers characteristic of mesenchymal stem cells (MSC). In mice that are genetically predisposed to...
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