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Article

Mesenchymal stromal cell mutations and wound healing contribute to the etiology of desmoid tumors.

Cancer research - 1 Jan 2012

Carothers Adelaide M, Rizvi Hira, Hasson Rian M, Heit Yvonne I, Davids Jennifer S, Bertagnolli Monica M, Cho Nancy L

Abstract excerpt

Desmoid tumors are nonmalignant neoplasms of mesenchymal origin that mainly contain fibroblast lineage cells. These tumors often occur in patients with familial adenomatous polyposis (FAP) coli who have germ line mutations in the APC gene. Given emerging data that has implicated multipotent mesencyhmal stromal cells (MSC) in the origin of mesenchymal tumors, we hypothesized that desmoid tumors may arise in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22094874
DOI: 10.1158/0008-5472.CAN-11-2819
PMCID: PMC3251735

Genes

FAP
APC
MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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