Clinical Activity of the γ-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors (Aggressive Fibromatosis).

doi:10.1200/JCO.2016.71.1994

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Article

Clinical Activity of the γ-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors (Aggressive Fibromatosis).

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 May 2017

Kummar Shivaani, O'Sullivan Coyne Geraldine, Do Khanh T, Turkbey Baris, Meltzer Paul S, Polley Eric, Choyke Peter L, Meehan Robert, Vilimas Rasa, Horneffer Yvonne, Juwara Lamin, Lih Ann, Choudhary Amul, Mitchell Sandra A, Helman Lee J, Doroshow James H, Chen Alice P

Abstract excerpt

Purpose Desmoid tumors (aggressive fibromatosis) arise from connective tissue cells or fibroblasts. In general, they are slow growing and do not metastasize; however, locally aggressive desmoid tumors can cause severe morbidity and loss of function. Disease recurrence after surgery and/or radiation and diagnosis of multifocal desmoid tumors highlight the need to develop effective systemic treatments for this...

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PMID: 28350521
DOI: 10.1200/JCO.2016.71.1994
PMCID: PMC5455706

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APC
CTNNB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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