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Article

High throughput screening identifies modulators of histone deacetylase inhibitors.

BMC genomics - 26 Jun 2014

Gaupel Ann-Christin, Begley Thomas, Tenniswood Martin

Abstract excerpt

BACKGROUND: Previous studies from our laboratory and others have demonstrated that in addition to altering chromatin acetylation and conformation, histone deacetylase inhibitors (HDACi) disrupt the acetylation status of numerous transcription factors and other proteins. A whole genome yeast deletion library screen was used to identify components of the transcriptional apparatus that modulate the sensitivity to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24968945
DOI: 10.1186/1471-2164-15-528
PMCID: PMC4089024

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