Identification and Characterization of Small Molecule Inhibitors of a Class I Histone Deacetylase from <i>Plasmodium falciparum</i>

Abstract excerpt

A library of approximately 2000 small molecules biased toward inhibition of histone deacetylases was assayed for antimalarial activity in a high-throughput P. falciparum viability assay. Active compounds were cross-analyzed for induction of histone hyperacetylation in a human myeloma cell line to identify HDAC inhibitors with selectivity for P. falciparum over the human host. To verify on-target selectivity,...

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