Article
Pael receptor is involved in dopamine metabolism in the nigrostriatal system.
Neuroscience research - 1 Dec 2007
Imai Yuzuru, Inoue Haruhisa, Kataoka Ayane, Hua-Qin Wang, Masuda Masao, Ikeda Toshio, Tsukita Kayoko, Soda Mariko, Kodama Tohru, Fuwa Tatsu, Honda Yoshiko, Kaneko Satoshi, Matsumoto Sadayuki, Wakamatsu Kazumasa, Ito Shosuke, Miura Masami, Aosaki Toshihiko, Itohara Shigeyoshi, Takahashi Ryosuke
Abstract excerpt
Pael receptor (Pael-R) has been identified as one of the substrates of Parkin, a ubiquitin ligase responsible for autosomal recessive juvenile Parkinsonism (AR-JP). When Parkin is inactivated, unfolded Pael-R accumulates in the endoplasmic reticulum and results in neuronal death by unfolded protein stress, suggesting that Pael-R has an important role in the pathogenesis of AR-JP. Here we report the analyses on...
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