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Article

Lyme disease in human DR4Dw4-transgenic mice.

The Journal of infectious diseases - 1 Jul 1995

Feng S, Barthold S W, Bockenstedt L K, Zaller D M, Fikrig E

Abstract excerpt

The evolution of Lyme arthritis in DR4-transgenic mice infected with Borrelia burgdorferi was studied because chronic Lyme arthritis in humans is associated with an increased frequency of the HLA-DR4 allele. B10 nontransgenic and DR4-transgenic mice expressing chimeric human-mouse major histocompatibility complex class II genes in which the human alpha 1 and beta 1 domains of DR4Dw4 replaced the corresponding...

Topics

Alleles
Animals
Antibody Formation
Borrelia burgdorferi Group
Enzyme-Linked Immunosorbent Assay
Genes, MHC Class II
HLA-DR4 Antigen
Humans
Lyme Disease
Mice
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred Strains

Mice, Transgenic

Source

Identifiers

PMID: 7797933
DOI: 10.1093/infdis/172.1.286

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7797933-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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