Article
New data on the world distribution of paraoxonase (PON1 Gln 192 --> Arg) gene frequencies.
Human biology - 1 Jun 2003
Scacchi R, Corbo R M, Rickards O, De Stefano G F
Abstract excerpt
The physiological role of human paraoxonase (PON), a serum enzyme that hydrolyzes organophosphate insecticides and nerve agents, is not clear. Of the three genes in the paraoxonase gene family, PON1 shows a polymorphism, Gln 192 --> Arg, governed by two common alleles named *Q and *R. These determine two different isoforms associated, respectively, with lower and higher activity towards paraoxon, a toxic...
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