Article
Variability of the paraoxonase gene (PON1) in Euro- and Afro-Brazilians.
Toxicology and applied pharmacology - 1 May 2002
Allebrandt Karla V, Souza Ricardo L R, Chautard-Freire-Maia Eleidi A
Abstract excerpt
The human high-density lipoprotein-associated paraoxonase (EC 3.1.1.2; PON1) plays a role in the hydrolysis of organophosphorus compounds and against the oxidative damage of low-density lipoprotein. In the present study, variants of PON1 (55 and 192) were investigated by PCR-RFLP and PCR-SSCA in Euro- (N = 101) and Afro-Brazilians (N = 70). The PON1*55 and PON1*192 allele frequencies were significantly different...
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