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Article

Genetic analysis of sick sinus syndrome in a family harboring compound CACNA1C and TTN mutations.

Molecular medicine reports - 1 May 2018

Zhu Yao-Bin, Luo Jie-Wei, Jiang Fen, Liu Gui

Abstract excerpt

Sick sinus syndrome (SSS) is a sinus node dysfunction characterized by severe sinus bradycardia. SSS results in insufficient blood supply to the brain, heart, kidneys, and other organs and is associated with the increased risk of sudden cardiac death. Bradyarrhythmia appears in the absence of any associated cardiac pathology and displays a genetic legacy. The present study identified a family with primary...

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Identifiers

PMID: 29568937
DOI: 10.3892/mmr.2018.8773
PMCID: PMC5928663

Genes

TTN

Variants

Provenance

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