Article
The role of DNA replication and isochores in generating mutation and silent substitution rate variance in mammals.
Genetical research - 1 Aug 1992
Eyre-Walker A
Abstract excerpt
It has been suggested that isochores are maintained by mutation biases, and that this leads to variation in the rate of mutation across the genome. A model of DNA replication is presented in which the probabilities of misincorporation and proofreading are affected by the composition and concentration of the free nucleotide pools. The relationship between sequence G+C content and the mutation rate is investigated....
Topics
- Animals
- Base Composition
- DNA Repair
- DNA Replication
- Genetic Variation
- Mammals
- Models, Genetic
- Mutation