A model for the correlation of mutation rate with GC content and the origin of GC-rich isochores.

doi:10.1007/BF00178846

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Article

A model for the correlation of mutation rate with GC content and the origin of GC-rich isochores.

Journal of molecular evolution - 1 May 1994

Gu X, Li W H

Abstract excerpt

Based on the biochemical kinetics of DNA replication and mutagenesis, including misincorporation and correction, a model has been developed for studying the relationships among the mutation rate (u), the G+C content of the sequence (f), and the G+C proportion in the nucleotide precursor pool (N)....

Topics

Base Composition
Cytosine
DNA
DNA Replication
Guanine
Humans
Mathematics
Models, Genetic
Mutation

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