Mammalian DNA replication: mutation biases and the mutation rate.

doi:10.1016/s0022-5193(05)80092-x

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Article

Mammalian DNA replication: mutation biases and the mutation rate.

Journal of theoretical biology - 21 Apr 1991

Wolfe K H

Abstract excerpt

Experimental studies have shown that the fidelity of DNA replication can be affected by the concentrations of free deoxyribonucleotides present in the cell. Replication of mammalian chromosomes is achieved using pools of newly-synthesized deoxyribonucleotides which fluctuate during the cell cycle...

Topics

Animals
Base Sequence
Cell Cycle
DNA Replication
Deoxyribonucleotides
Mathematics
Models, Genetic
Mutation

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