Thin filament interaction and Ca2+-desensitization effect of the C-terminal end peptide of cardiac troponin T and loss of function in hypertrophic cardiomyopathy mutants.

Abstract excerpt

Troponin T (TnT), the tropomyosin (Tm)-binding subunit of troponin, plays a central role in regulating striated muscle contractility. The recently identified Tm-binding site 3 in the highly conserved C-terminal end segment of TnT has a troponin I (TnI)-like inhibitory function. A restrictive proteolytic removal of the N-terminal hypervariable region (amino acids 1-71) of cardiac TnT (cTnT-ND) in vivo in...

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