Article
The influence of CYP3A5 genotype on dexamethasone induction of CYP3A activity in African Americans.
Drug metabolism and disposition: the biological fate of chemicals - 1 Aug 2008
Roberts Patrick J, Rollins Kristan D, Kashuba Angela D M, Paine Mary F, Nelsen Andrew C, Williams Eric E, Moran Cassandra, Lamba Jatinder K, Schuetz Erin G, Hawke Roy L
Abstract excerpt
The CYP3A5(*)1 allele has been associated with differences in the metabolism of some CYP3A substrates. CYP3A5 polymorphism may also influence susceptibility for certain drug interactions. We have previously noted a correlation between basal CYP3A activity and the inductive effects of dexamethasone using the erythromycin breath test (ERBT). To determine whether CYP3A5 polymorphism influences induction of CYP3A...
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