Phenotypic alterations in fibroblasts and fibrosarcoma cells that overexpress latent transforming growth factor-beta 1.

doi:10.1210/endo.130.5.1374006

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Article

Phenotypic alterations in fibroblasts and fibrosarcoma cells that overexpress latent transforming growth factor-beta 1.

Endocrinology - 1 May 1992

Beauchamp R D, Sheng H M, Bascom C C, Miller D A, Lyons R M, Torre-Amione G, Moses H L

Abstract excerpt

Mouse embryo-derived AKR-2B fibroblasts and murine fibrosarcoma cells (the 1591 cell line) were transfected with a murine transforming growth factor-beta 1 (TGF beta 1) cDNA under the transcriptional control of either the simian virus-40 early promoter or the cytomegalovirus promoter/enhancer. Selected clones secreted 2- to 4-fold more TGF beta-competing activity into their media than the parental cell line or...

Topics

Animals
Blotting, Northern
Cell Line
Embryo, Mammalian
Fibroblasts
Fibrosarcoma
Gene Expression
Kinetics
Mice
Mice, Inbred C3H
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmids

Poly A

RNA

RNA, Messenger

Receptors, Cell Surface

Receptors, Transforming Growth Factor beta

Sarcoma, Experimental

Source

Open in PubMed

Identifiers

PMID: 1374006
DOI: 10.1210/endo.130.5.1374006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1374006-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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