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Article

Pro-opiomelanocortin gene is associated with serum leptin levels in lean but not in obese individuals.

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 Oct 2003

Suviolahti E, Ridderstråle M, Almgren P, Klannemark M, Melander O, Carlsson E, Carlsson M, Hedenbro J, Orho-Melander M

Abstract excerpt

OBJECTIVE: Mutations in the pro-opiomelanocortin and melanocortin 4 receptor genes (POMC and MC4R) cause monogenic obesity, and the POMC locus (2p21) has been linked to leptin levels and body mass index (BMI). We searched for monogenic obesity due to mutations in POMC and MC4R among morbidly obese Swedes and studied the association of POMC variants with BMI and serum leptin levels. DESIGN: MC4R and POMC were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single-Stranded Conformational

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Share to Receptor, Melanocortin, Type 4

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Source

Identifiers

PMID: 14513068
DOI: 10.1038/sj.ijo.0802392

Genes

POMC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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