Article
[Monogenic obesity in human].
Nihon rinsho. Japanese journal of clinical medicine - 1 Feb 2013
Onigata Kazumichi
Abstract excerpt
Obesity is a heterogeneous pathologic condition that is driven by interactions between multiple genetic and environmental factors. The discovery of leptin has provided the useful clue to the molecular dissection of central pathways involved in the regulation of food intake and body weight. Monogenic obesity in human has been documented. Several obesity causing genes within the leptin-POMC-melanocortin axis have...
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