Article
Next-generation sequencing of the monogenic obesity genes LEP, LEPR, MC4R, PCSK1 and POMC in a Norwegian cohort of patients with morbid obesity and normal weight controls.
Molecular genetics and metabolism - 1 May 2017
Nordang Gry B N, Busk Øyvind L, Tveten Kristian, Hanevik Hans Ivar, Fell Anne Kristin M, Hjelmesæth Jøran, Holla Øystein L, Hertel Jens K
Abstract excerpt
BACKGROUND: Rare sequence variants in at least five genes are known to cause monogenic obesity. In this study we aimed to investigate the prevalence of, and characterize, rare coding and splice site variants in LEP, LEPR, MC4R, PCSK1 and POMC in patients with morbid obesity and normal weight controls. METHOD: Targeted next-generation sequencing of all exons in LEP, LEPR, MC4R, PCSK1 and POMC was performed in 485...
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