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Article

A decrease in the expression of CD63 tetraspanin protein elevates invasive potential of human melanoma cells

1 Aug 2003

Abstract excerpt

CD63, which belongs to the tetraspanin membrane proteins, has been proposed to play an important role in inhibiting melanoma metastasis. To determine whether reduction of CD63 expression, which frequently occurs in the malignant progression of human melanoma, is responsible for metastasis promotion, we transfected the antisense CD63 cDNA into MelJuso melanoma cells having endogenous CD63 expression. The antisense...

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PMID: 14508073
DOI: 10.1038/emm.2003.43

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