Article
Overexpression of the human melanoma-associated antigen ME491 partially suppresses in vivo malignant phenotypes of H-ras-transformed NIH3T3 cells in athymic nude mice.
Melanoma research - 1 Jan 2000
Hotta H, Hara I, Miyamoto H, Homma M
Abstract excerpt
H-ras-transformed NIH3T3 cells that overexpressed a human melanoma-associated antigen ME491 (44-3H) were generated by transfection with the cloned ME491 antigen gene followed by a 'panning' selection, and effects of the antigen overexpression on H-ras-mediated malignant phenotypes were studied. A...
Topics
- 3T3 Cells
- Animals
- Antigens, CD
- Antigens, Neoplasm
- Cell Line, Transformed
- Gene Expression Regulation, Neoplastic
- Genes, Tumor Suppressor
- Genes, ras
- Melanoma
- Mice
- Mice, Nude
- Neoplasm Transplantation
- Phenotype
- Platelet Membrane Glycoproteins
- Recombinant Proteins
- Tetraspanin 30