Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

APOE genotype affects outcome in a murine model of sepsis: implications for a new treatment strategy.

Anaesthesia and intensive care - 1 Jan 2009

Wang H, Christensen D J, Vitek M P, Sullivan P M, Laskowitz D T

Abstract excerpt

In this study, we assessed whether apolipoprotein E (APOE) polymorphism affects inflammatory responses and mortality in the caecal ligation and puncture model of peritonitis. In addition, we determined the effects of APOE mimetic peptide administration in this sepsis model. Differences in survival between targeted replacement mice expressing the human APOE3 allele (APOE3TR) and the APOE4 allele (APOE4TR) mice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein E3
Share to Apolipoprotein E4
Share to Granulocyte-Macrophage Colony-Stimulating Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukins

Share to Ligation

Share to Sepsis

Share to Survival Rate

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 19157344
DOI: 10.1177/0310057X0903700111

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

APOE genotype affects outcome in a murine model of sepsis: implications for a new treatment strategy.PMID 19157344Read ↗

APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response.Semantic proximity Read ↗

Inhibition of Cholesteryl Ester Transfer Protein Preserves High-Density Lipoprotein Cholesterol and Improves Survival in Sepsis.Semantic proximity Read ↗

Apolipoprotein E genotype affects innate susceptibility to Listeria monocytogenes infection in aged male mice.Semantic proximity Read ↗

Presence of the apolipoprotein E-ε4 allele is associated with an increased risk of sepsis progression.Semantic proximity Read ↗

An exaggerated inflammatory response after CLP correlates with a negative outcome.Semantic proximity Read ↗

Apolipoprotein E‐deficient mice have an impaired immune response to <i>Klebsiella pneumoniae</i>Semantic proximity Read ↗

Bacterial peptidoglycan-associated lipoprotein is released into the bloodstream in gram-negative sepsis and causes inflammation and death in mice.Semantic proximity Read ↗

APOE polymorphism is associated with risk of severe sepsis in surgical patients.Semantic proximity Read ↗

Effects of apoE genotype on macrophage inflammation and heme oxygenase-1 expression.Semantic proximity Read ↗

Genetic polymorphisms of apolipoprotein E4 and tumor necrosis factor beta as predisposing factors for increased inflammatory cytokines after cardiopulmonary bypass.Semantic proximity Read ↗

Essential involvement of CX3CR1-mediated signals in the bactericidal host defense during septic peritonitis.Semantic proximity Read ↗

Modulation of lipid and protein mediators of inflammation by cytosolic phospholipase A2alpha during experimental sepsis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.