Article
Lethality of bypass polymerases in Escherichia coli cells with a defective clamp loader complex of DNA polymerase III.
Molecular microbiology - 1 Oct 2003
Viguera Enrique, Petranovic Mirjana, Zahradka Davor, Germain Karine, Ehrlich Dusko S, Michel Bénédicte
Abstract excerpt
Escherichia coli DNA polymerase III (Pol III) is one of the best studied replicative DNA polymerases. Here we report the properties of an E. coli mutant that lacks one of the subunits of the Pol III clamp loader complex, Psi (psi), as a result of the complete inactivation of the holD gene. We show that, in this mutant, chronic induction of the SOS response in a RecFOR-dependent way leads to lethality at high...
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