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Article

ssb gene duplication restores the viability of ΔholC and ΔholD Escherichia coli mutants.

PLoS genetics - 1 Oct 2014

Duigou Stéphane, Silvain Maud, Viguera Enrique, Michel Bénédicte

Abstract excerpt

The HolC-HolD (χψ) complex is part of the DNA polymerase III holoenzyme (Pol III HE) clamp-loader. Several lines of evidence indicate that both leading- and lagging-strand synthesis are affected in the absence of this complex. The Escherichia coli ΔholD mutant grows poorly and suppressor mutations that restore growth appear spontaneously. Here we show that duplication of the ssb gene, encoding the single-stranded...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 25329071
DOI: 10.1371/journal.pgen.1004719
PMCID: PMC4199511

Genes

SSB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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