Article
Competitive fitness during feast and famine: how SOS DNA polymerases influence physiology and evolution in Escherichia coli.
Genetics - 1 Jun 2013
Corzett Christopher H, Goodman Myron F, Finkel Steven E
Abstract excerpt
Escherichia coli DNA polymerases (Pol) II, IV, and V serve dual roles by facilitating efficient translesion DNA synthesis while simultaneously introducing genetic variation that can promote adaptive evolution. Here we show that these alternative polymerases are induced as cells transition from exponential to long-term stationary-phase growth in the absence of induction of the SOS regulon by external agents that...
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